As South Africa geared itself to host the FIFA World Cup, Gun Free SA kicked off 2010 by partnering with the Secretariat for Police on the 2010 national firearms amnesty.
During the amnesty, held from 11 January to 11 April 2010, the public was given immunity from prosecution for being in illegal possession of firearms or ammunition.
Gun Free SA played a leading role in the amnesty; monitoring the process, thereby ensuring civil society oversight and transparency and assisting the police with communicating the amnesty message.

At the close of the 2010 firearms amnesty a total of 42,329 firearms and 450,389 rounds of ammunition had been handed in.